Kenny Moore

James Martin Stem Cell Fellow | James Martin Trust | Brasenose College | kenny.moore@path.ox.ac.uk
Kenny Moore is a James Martin Stem Cell Research Fellow,
using stem cells to investigate host-pathogen interactions of HIV-1.  Genetic manipulation plays an important role in uncovering the function of various proteins in any system, and using stem cell-derived macrophages, a technology developed within the James laboratory, Kenny is creating genetically modified macrophages for the study of HIV-1 infection.  Genetic manipulation of stem cells is also of paramount importance for their development as a therapeutic tool and Kenny is also involved in designing new strategies to accomplish this aim.

 

After graduating from Oxford with a degree in Biological Sciences, Kenny studied at Imperial College London, first obtaining a Masters degree in the Molecular Biology of Viruses, and subsequently completing a PhD in Gene Therapy approaches to HBV infection. Kenny then secured a post-doctoral research position within the National Cancer Institute at Frederick, Maryland, within the retrovirology section investigating factors involved in recombination of HIV-1.  This lead to the identification of the site and timing of dimerisation of the two strands of HIV-1 genomic RNA that become packaged into the virion ( J Virol 2007 and PLoS Pathog. 2009 ). Upon returning to the UK, Kenny acquired a post-doctoral research position within the James Lab on an NIH funded project to exploit aptamer technology for antiviral microbicides (J Biol Chem 2011) and has subsequently become one of the first James Martin Stem Cell Research Fellows.

 

Publications
Generation of Neutralising Aptamers Against HSV-2: Potential Components of Multivalent Microbicides.
M.D.Moore, D.H.J.Bunka, M.Forzan, P.Spear, P.G.Stockley, I.McGowan and W.James.
Journal of General Virology. (2011) Jul;92(Pt 7):1493-9.
Multiple barriers to Recombination between Divergent HIV-1 Varients Revealed by a Dual-Marker Recombination Assay.
O.A.Nikolaitchik, A.Galli, M.D.Moore, V.K.Pathak and W-S.Hu.
Journal of Molecular Biology. (2011) Apr 407(4):521-31.
Protection of HIV Neutralizing Aptamers Against Rectal and Vaginal Nucleases: Implications for RNA-Based Therapeutics.
M.D.Moore, J.Cookson, V.K.Coventry, B.Sproat, L.Rabe, R.D.Cranston, I.McGowan, and W.James.
Journal of Biological Chemistry. (2011) Jan 286(4): 2526-35.
Delineation of the Preferences and Requirements of Human Immunodeficiency Virus Type 1 Dimerization Initiation Signal Using an in Vivo Cell-based Selection Approach.
I.T.M.Hussein, N.Ni, A.Galli, J.Chen, M.D.Moore, and W-S.Hu.
Journal of Virology (2010) 84(13):6866-75.
Probing the HIV-1 Genomic RNA Trafficking Pathway and Dimerization by Genetic Recombination and Single Virion Analyses.
M.D.Moore, O.Nikolaitchik, J.Chen, M-L.Hammarskjold, D.Rekosh and W-S.Hu.
PLoS Pathogens (2009). Oct 5(10).
HIV-1 Dimerization: It takes Two to Tango.
M.D.Moore, W-S. Hu.
AIDS Reviews (2009) Apr-Jun 11(2): 91-102.
APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA.
R.A.Russell, M.D.Moore, W-S. Hu, and V.K.Pathak.
Retrovirology (2009) Feb 6(1): 16
HIV-1 recombination: An experimental assay and a phylogenetic approach.
M.D.Moore, M.P.S.Chin and W-S.Hu.
Methods in Molecular Biology (2009) 485: 87-105.
Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: Effects on virion morphogenesis and RNA maturation.
M.D.Moore, W.Fu, F.Sohelian, K.Nagashima, R.G.Ptak, V.K.Pathak and W-S.Hu.
Virology (2008) Sep 379(1): 152-160.
Dimer Initiation Signal of Human Immunodeficiency Virus type I: Its role in Partner Selection during RNA Copackaging and Its Effects on Recombination.
M.D.Moore, W.Fu, O.Nikolaitchik, J.Chen, R.G.Ptak and W-S.Hu.
Journal of Virology (2007)  81 (8): 4002-4011.
The Foamy Virus Bet Protein Functions as a Novel Inhibitor of the APOBEC3 Family of Innate Antiretroviral Defence Factors.
R.A.Russell, H.L.Weigand, M.D.Moore, A.Schäfer, M.O.McClure, B.R.Cullen.
Journal of Virology (2005)  79: 8724-8731.
Stable Inhibition of Hepatitis B Virus Proteins by Small Interfering RNA expressed from Viral Vectors.
M.D.Moore, M.J.McGarvey, R.A.Russell, B.R.Cullen and M.O.McClure.
Journal of Gene Medicine (2005)  7: 918-925.