- Macrophages from human pluripotent stem cells September 24, 2018
- Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism September 7, 2018
- FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex August 30, 2018
- Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease August 1, 2018
- Multiplex High-Throughput Targeted Proteomic Assay to Identify Induced Pluripotent Stem Cells July 8, 2018
DPhil Student | Wellcome Trust | Keble College | firstname.lastname@example.org
Alun is DPhil student on the Wellcome Trust Infection, Immunology, and Translational Medicine (IITM) doctoral programme. He started his journey into science doing a BSc Biomedical Sciences at UCL, from which he transferred to a BSc in Infection and Immunology for his final year. In this year he focussed his interests in infectious diseases onto virology, carrying out a dissertation project in the Tower’s lab working on new drug therapies for HIV-1 aiming to block interactions with host co-factors.
It was in the Tower’s lab that he first encountered and developed an interest in the Cyclophilins, a family of proteins with unclear functions and often found to interact with viruses. He wanted to see if they may be involved in the innate/antiviral immune response, but to achieve this he needed to knock out each family member. This ultimately led him to the James lab, where using their stem cell derived macrophages he has been able to explore the role of Cyclophilins in innate immunity and viral infections.