- Multiplex High-Throughput Targeted Proteomic Assay to Identify Induced Pluripotent Stem Cells August 12, 2017
- MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons July 18, 2017
- Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease May 15, 2017
- Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease April 4, 2017
- LRRK2 in peripheral and central nervous system innate immunity: Its link to Parkinson’s disease March 20, 2017
I started studying biology at University of Zurich in 2004 and obtained the Bachelor of Science in Biology in 2007.
I did my master thesis in the group of Prof. Wolfgang Berger (Institute of Medical Genetics, University of Zurich, Schwerzenbach) “LRP5 and LRP5L mutation screening in patients with Norrie disease pseudoglioma-related phenotypes& Expression analysis of potential Norrin targets in Norrin knockout mouse cerebellum” and obtained the Master of Science in Biology, Neurosciences, from the University of Zurich in 2009.
The same year I started as a PhD student in the group of Prof. Reinhard Seger Children’s Hospital Zürich and joined the Microbiology and Immunology PhD program . In 2013, I finished my thesis “Development of a Silencing Resistant Myelospecific Next Generation Gene Therapy Vector for Gene Therapy of the p47phox-deficient Form of Chronic Granulomatous Disease” and published part of my results (C. Brendel, Hum Gene Ther Methods. 2013 Jun;24(3):151-9.).
In 2013 I awarded a Swiss National Fonds early Postdoc Mobility Fellowship to investigate the role of microglia in alpha-synuclein related loss of dopaminergic neurons in Parkinson’s disease with help of iPSC based microglial and neuronal model systems in the William James lab.