Selected Recent Publications

1: Mistry P, Barmania F, Mellet J, Peta K, Strydom A, Viljoen IM, James W,
Gordon S, Pepper MS. SARS-CoV-2 Variants, Vaccines, and Host Immunity. Front
Immunol. 2022 Jan 3;12:809244. doi: 10.3389/fimmu.2021.809244. PMID: 35046961;
PMCID: PMC8761766.

2: Gothe F, Stremenova Spegarova J, Hatton CF, Griffin H, Sargent T, Cowley SA,
James W, Roppelt A, Shcherbina A, Hauck F, Reyburn HT, Duncan CJA, Hambleton S.
Aberrant inflammatory responses to type I interferon in STAT2 or IRF9
deficiency. J Allergy Clin Immunol. 2022 Feb 17:S0091-6749(22)00185-3. doi:
10.1016/j.jaci.2022.01.026. Epub ahead of print. PMID: 35182547.

3: Tomic A, Skelly DT, Ogbe A, O’Connor D, Pace M, Adland E, Alexander F, Ali M,
Allott K, Azim Ansari M, Belij-Rammerstorfer S, Bibi S, Blackwell L, Brown A,
Brown H, Cavell B, Clutterbuck EA, de Silva T, Eyre D, Lumley S, Flaxman A,
Grist J, Hackstein CP, Halkerston R, Harding AC, Hill J, James T, Jay C, Johnson
SA, Kronsteiner B, Lie Y, Linder A, Longet S, Marinou S, Matthews PC, Mellors J,
Petropoulos C, Rongkard P, Sedik C, Silva-Reyes L, Smith H, Stockdale L, Taylor
S, Thomas S, Tipoe T, Turtle L, Vieira VA, Wrin T; OPTIC Clinical Group; PITCH
Study Group; C-MORE Group, Pollard AJ, Lambe T, Conlon CP, Jeffery K, Travis S,
Goulder P, Frater J, Mentzer AJ, Stafford L, Carroll MW, James WS, Klenerman P,
Barnes E, Dold C, Dunachie SJ. Divergent trajectories of antiviral memory after
SARS-CoV-2 infection. Nat Commun. 2022 Mar 10;13(1):1251. doi:
10.1038/s41467-022-28898-1. PMID: 35273178; PMCID: PMC8913789.

4: Huang KA, Zhou D, Tan TK, Chen C, Duyvesteyn HME, Zhao Y, Ginn HM, Qin L,
Rijal P, Schimanski L, Donat R, Harding A, Gilbert-Jaramillo J, James W, Tree
JA, Buttigieg K, Carroll M, Charlton S, Lien CE, Lin MY, Chen CP, Cheng SH, Chen
X, Lin TY, Fry EE, Ren J, Ma C, Townsend AR, Stuart DI. Structures and
therapeutic potential of anti-RBD human monoclonal antibodies against SARS-
CoV-2. Theranostics. 2022 Jan 1;12(1):1-17. doi: 10.7150/thno.65563. PMID:
34987630; PMCID: PMC8690919.

5: Tan LY, Komarasamy TV, James W, Balasubramaniam VRMT. Host Molecules
Regulating Neural Invasion of Zika Virus and Drug Repurposing Strategy. Front
Microbiol. 2022 Mar 4;13:743147. doi: 10.3389/fmicb.2022.743147. PMID: 35308394;
PMCID: PMC8931420.

6: Komarasamy TV, Adnan NAA, James W, Balasubramaniam VRMT. Zika Virus
Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms
Involved. Front Immunol. 2022 Mar 16;13:773191. doi: 10.3389/fimmu.2022.773191.
PMID: 35371036; PMCID: PMC8966389.

7: Komarasamy TV, Adnan NAA, James W, Balasubramaniam VR. Finding a chink in the
armor: Update, limitations, and challenges toward successful antivirals against
flaviviruses. PLoS Negl Trop Dis. 2022 Apr 28;16(4):e0010291. doi:
10.1371/journal.pntd.0010291. PMID: 35482672; PMCID: PMC9049358.

8: Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali
M, Hering LM, Meardon N, Austin J, Brown R, Skelly D, Gillson N, Dobson SL,
Cross A, Sandhar G, Kilby JA, Tyerman JK, Nicols AR, Spegarova JS, Mehta H,
Hornsby H, Whitham R, Conlon CP, Jeffery K, Goulder P, Frater J, Dold C, Pace M,
Ogbe A, Brown H, Ansari MA, Adland E, Brown A, Chand M, Shields A, Matthews PC,
Hopkins S, Hall V, James W, Rowland-Jones SL, Klenerman P, Dunachie S, Richter
A, Duncan CJA, Barnes E, Carroll M, Turtle L, de Silva TI; PITCH Consortium.
T-cell and antibody responses to first BNT162b2 vaccine dose in previously
infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective
cohort study. Lancet Microbe. 2022 Jan;3(1):e21-e31. doi:
10.1016/S2666-5247(21)00275-5. Epub 2021 Nov 9. PMID: 34778853; PMCID:
PMC8577846.

9: Sabate-Soler S, Nickels SL, Saraiva C, Berger E, Dubonyte U, Barmpa K, Lan
YJ, Kouno T, Jarazo J, Robertson G, Sharif J, Koseki H, Thome C, Shin JW, Cowley
SA, Schwamborn JC. Microglia integration into human midbrain organoids leads to
increased neuronal maturation and functionality. Glia. 2022 Jul;70(7):1267-1288.
doi: 10.1002/glia.24167. Epub 2022 Mar 9. PMID: 35262217.

10: Ertesvåg NU, Xiao J, Zhou F, Ljostveit S, Sandnes H, Lartey S, Sævik M,
Hansen L, Madsen A, Mohn KGI, Fjelltveit E, Olofsson JS, Tan TK, Rijal P,
Schimanski L, Øyen S, Brokstad KA, Dunachie S, Jämsén A, James WS, Harding AC,
Harvala H, Nguyen D, Roberts D; PHE Virology group, Zambon M; Oxford
collaborative group, Townsend A; Bergen COVID-19 Research Group, Langeland N,
Cox RJ. A rapid antibody screening haemagglutination test for predicting
immunity to SARS-CoV-2 variants of concern. Commun Med (Lond). 2022 Apr 5;2:36.
doi: 10.1038/s43856-022-00091-x. PMID: 35603265; PMCID: PMC9053181.

11: Peng Y, Felce SL, Dong D, Penkava F, Mentzer AJ, Yao X, Liu G, Yin Z, Chen
JL, Lu Y, Wellington D, Wing PAC, Dominey-Foy DCC, Jin C, Wang W, Hamid MA,
Fernandes RA, Wang B, Fries A, Zhuang X, Ashley N, Rostron T, Waugh C, Sopp P,
Hublitz P, Beveridge R, Tan TK, Dold C, Kwok AJ, Rich-Griffin C, Dejnirattisa W,
Liu C, Kurupati P, Nassiri I, Watson RA, Tong O, Taylor CA, Kumar Sharma P, Sun
B, Curion F, Revale S, Garner LC, Jansen K, Ferreira RC, Attar M, Fry JW,
Russell RA; COMBAT Consortium, Stauss HJ, James W, Townsend A, Ho LP, Klenerman
P, Mongkolsapaya J, Screaton GR, Dendrou C, Sansom SN, Bashford-Rogers R, Chain
B, Smith GL, McKeating JA, Fairfax BP, Bowness P, McMichael AJ, Ogg G, Knight
JC, Dong T. An immunodominant NP_105-113-B*07:02 cytotoxic T cell
response controls viral replication and is associated with less severe COVID-19
disease. Nat Immunol. 2022 Jan;23(1):50-61. doi: 10.1038/s41590-021-01084-z.
Epub 2021 Dec 1. PMID: 34853448; PMCID: PMC8709787.

12: Lee JY, Wing PA, Gala DS, Noerenberg M, Järvelin AI, Titlow J, Zhuang X,
Palmalux N, Iselin L, Thompson MK, Parton RM, Prange-Barczynska M, Wainman A,
Salguero FJ, Bishop T, Agranoff D, James W, Castello A, McKeating JA, Davis I.
Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new
paradigm for infection dynamics and variant differences. Elife. 2022 Jan
20;11:e74153. doi: 10.7554/eLife.74153. PMID: 35049501; PMCID: PMC8776252.

13: Qiang M, Ma P, Li Y, Liu H, Harding A, Min C, Wang F, Liu L, Yuan M, Ji Q,
Tao P, Shi X, Li Z, Li T, Wang X, Zhang Y, Wu NC, Lee CD, Zhu X, Gilbert-
Jaramillo J, Zhang C, Saxena A, Huang X, Wang H, James W, Dwek RA, Wilson IA,
Yang G, Lerner RA. Neutralizing Antibodies to SARS-CoV-2 Selected from a Human
Antibody Library Constructed Decades Ago. Adv Sci (Weinh). 2022
Jan;9(1):e2102181. doi: 10.1002/advs.202102181. Epub 2021 Oct 29. PMID:
34716683; PMCID: PMC8646600.

Full list

2021 publications

1: Mistry P, Barmania F, Mellet J, Peta K, Strydom A, Viljoen IM, James W,
Gordon S, Pepper MS. SARS-CoV-2 Variants, Vaccines, and Host Immunity. Front
Immunol. 2022 Jan 3;12:809244. doi: 10.3389/fimmu.2021.809244. PMID: 35046961;
PMCID: PMC8761766.

2: Vahsen BF, Gray E, Thompson AG, Ansorge O, Anthony DC, Cowley SA, Talbot K,
Turner MR. Non-neuronal cells in amyotrophic lateral sclerosis – from
pathogenesis to biomarkers. Nat Rev Neurol. 2021 Jun;17(6):333-348. doi:
10.1038/s41582-021-00487-8. Epub 2021 Apr 29. PMID: 33927394.

3: Skelly DT, Harding AC, Gilbert-Jaramillo J, Knight ML, Longet S, Brown A,
Adele S, Adland E, Brown H; Medawar Laboratory Team, Tipton T, Stafford L,
Mentzer AJ, Johnson SA, Amini A; OPTIC (Oxford Protective T cell Immunology for
COVID-19) Clinical Group, Tan TK, Schimanski L, Huang KA, Rijal P; PITCH
(Protective Immunity T cells in Health Care Worker) Study Group; C-MORE/PHOSP-C
Group, Frater J, Goulder P, Conlon CP, Jeffery K, Dold C, Pollard AJ, Sigal A,
de Oliveira T, Townsend AR, Klenerman P, Dunachie SJ, Barnes E, Carroll MW,
James WS. Two doses of SARS-CoV-2 vaccination induce robust immune responses to
emerging SARS-CoV-2 variants of concern. Nat Commun. 2021 Aug 17;12(1):5061.
doi: 10.1038/s41467-021-25167-5. PMID: 34404775; PMCID: PMC8371089.

4: Dejnirattisai W, Zhou D, Ginn HM, Duyvesteyn HME, Supasa P, Case JB, Zhao Y,
Walter TS, Mentzer AJ, Liu C, Wang B, Paesen GC, Slon-Campos J, López-Camacho C,
Kafai NM, Bailey AL, Chen RE, Ying B, Thompson C, Bolton J, Fyfe A, Gupta S, Tan
TK, Gilbert-Jaramillo J, James W, Knight M, Carroll MW, Skelly D, Dold C, Peng
Y, Levin R, Dong T, Pollard AJ, Knight JC, Klenerman P, Temperton N, Hall DR,
Williams MA, Paterson NG, Bertram FKR, Siebert CA, Clare DK, Howe A, Radecke J,
Song Y, Townsend AR, Huang KA, Fry EE, Mongkolsapaya J, Diamond MS, Ren J,
Stuart DI, Screaton GR. The antigenic anatomy of SARS-CoV-2 receptor binding
domain. Cell. 2021 Apr 15;184(8):2183-2200.e22. doi: 10.1016/j.cell.2021.02.032.
Epub 2021 Feb 18. PMID: 33756110; PMCID: PMC7891125.

5: Wing PAC, Keeley TP, Zhuang X, Lee JY, Prange-Barczynska M, Tsukuda S, Morgan
SB, Harding AC, Argles ILA, Kurlekar S, Noerenberg M, Thompson CP, Huang KA,
Balfe P, Watashi K, Castello A, Hinks TSC, James W, Ratcliffe PJ, Davis I,
Hodson EJ, Bishop T, McKeating JA. Hypoxic and pharmacological activation of HIF
inhibits SARS-CoV-2 infection of lung epithelial cells. Cell Rep. 2021 Apr
20;35(3):109020. doi: 10.1016/j.celrep.2021.109020. Epub 2021 Apr 5. PMID:
33852916; PMCID: PMC8020087.

6: Zhou D, Dejnirattisai W, Supasa P, Liu C, Mentzer AJ, Ginn HM, Zhao Y,
Duyvesteyn HME, Tuekprakhon A, Nutalai R, Wang B, Paesen GC, Lopez-Camacho C,
Slon-Campos J, Hallis B, Coombes N, Bewley K, Charlton S, Walter TS, Skelly D,
Lumley SF, Dold C, Levin R, Dong T, Pollard AJ, Knight JC, Crook D, Lambe T,
Clutterbuck E, Bibi S, Flaxman A, Bittaye M, Belij-Rammerstorfer S, Gilbert S,
James W, Carroll MW, Klenerman P, Barnes E, Dunachie SJ, Fry EE, Mongkolsapaya
J, Ren J, Stuart DI, Screaton GR. Evidence of escape of SARS-CoV-2 variant
B.1.351 from natural and vaccine-induced sera. Cell. 2021 Apr
29;184(9):2348-2361.e6. doi: 10.1016/j.cell.2021.02.037. Epub 2021 Feb 23. PMID:
33730597; PMCID: PMC7901269.

7: Mendonça L, Howe A, Gilchrist JB, Sheng Y, Sun D, Knight ML, Zanetti-
Domingues LC, Bateman B, Krebs AS, Chen L, Radecke J, Li VD, Ni T, Kounatidis I,
Koronfel MA, Szynkiewicz M, Harkiolaki M, Martin-Fernandez ML, James W, Zhang P.
Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress. Nat
Commun. 2021 Jul 30;12(1):4629. doi: 10.1038/s41467-021-24887-y. PMID: 34330917;
PMCID: PMC8324836.

8: Cahill TJ, Sun X, Ravaud C, Villa Del Campo C, Klaourakis K, Lupu IE, Lord
AM, Browne C, Jacobsen SEW, Greaves DR, Jackson DG, Cowley SA, James W,
Choudhury RP, Vieira JM, Riley PR. Tissue-resident macrophages regulate
lymphatic vessel growth and patterning in the developing heart. Development.
2021 Feb 3;148(3):dev194563. doi: 10.1242/dev.194563. PMID: 33462113; PMCID:
PMC7875498.

9: Reich M, Paris I, Ebeling M, Dahm N, Schweitzer C, Reinhardt D, Schmucki R,
Prasad M, Köchl F, Leist M, Cowley SA, Zhang JD, Patsch C, Gutbier S, Britschgi
M. Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of
Human iPSC-Derived Microglia. Front Immunol. 2021 Feb 3;11:617860. doi:
10.3389/fimmu.2020.617860. PMID: 33613545; PMCID: PMC7887311.

10: Supasa P, Zhou D, Dejnirattisai W, Liu C, Mentzer AJ, Ginn HM, Zhao Y,
Duyvesteyn HME, Nutalai R, Tuekprakhon A, Wang B, Paesen GC, Slon-Campos J,
López-Camacho C, Hallis B, Coombes N, Bewley KR, Charlton S, Walter TS, Barnes
E, Dunachie SJ, Skelly D, Lumley SF, Baker N, Shaik I, Humphries HE, Godwin K,
Gent N, Sienkiewicz A, Dold C, Levin R, Dong T, Pollard AJ, Knight JC, Klenerman
P, Crook D, Lambe T, Clutterbuck E, Bibi S, Flaxman A, Bittaye M, Belij-
Rammerstorfer S, Gilbert S, Hall DR, Williams MA, Paterson NG, James W, Carroll
MW, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Reduced
neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
Cell. 2021 Apr 15;184(8):2201-2211.e7. doi: 10.1016/j.cell.2021.02.033. Epub
2021 Feb 18. PMID: 33743891; PMCID: PMC7891044.

11: Ng J, Barral S, De La Fuente Barrigon C, Lignani G, Erdem FA, Wallings R,
Privolizzi R, Rossignoli G, Alrashidi H, Heasman S, Meyer E, Ngoh A, Pope S,
Karda R, Perocheau D, Baruteau J, Suff N, Antinao Diaz J, Schorge S, Vowles J,
Marshall LR, Cowley SA, Sucic S, Freissmuth M, Counsell JR, Wade-Martins R,
Heales SJR, Rahim AA, Bencze M, Waddington SN, Kurian MA. Gene therapy restores
dopamine transporter expression and ameliorates pathology in iPSC and mouse
models of infantile parkinsonism. Sci Transl Med. 2021 May 19;13(594):eaaw1564.
doi: 10.1126/scitranslmed.aaw1564. PMID: 34011628; PMCID: PMC7612279.

12: Zhang P, Mendonca L, Howe A, Gilchrist J, Sun D, Knight M, Zanetti-Domingues
L, Bateman B, Krebs AS, Chen L, Radecke J, Sheng Y, Li V, Ni T, Kounatidis I,
Koronfel M, Szynkiewicz M, Harkiolaki M, Martin-Fernandez M, James W.
Correlative Multi-scale Cryo-imaging Unveils SARS-CoV-2 Assembly and Egress. Res
Sq [Preprint]. 2021 Jan 19:rs.3.rs-134794. doi: 10.21203/rs.3.rs-134794/v1.
Update in: Nat Commun. 2021 Jul 30;12(1):4629. PMID: 33501431; PMCID:
PMC7836121.

13: Lee LJ, Komarasamy TV, Adnan NAA, James W, Rmt Balasubramaniam V. Hide and
Seek: The Interplay Between Zika Virus and the Host Immune Response. Front
Immunol. 2021 Oct 21;12:750365. doi: 10.3389/fimmu.2021.750365. PMID: 34745123;
PMCID: PMC8566937.

14: Sanghani HR, Jagannath A, Humberstone T, Ebrahimjee F, Thomas JM, Churchill
GC, Cipriani A, Attenburrow MJ, Perestenko OV, Cowley SA, Cader MZ, Peirson SN,
Harrison PJ, Foster RG, Goodwin GM, Vasudevan SR. Patient fibroblast circadian
rhythms predict lithium sensitivity in bipolar disorder. Mol Psychiatry. 2021
Sep;26(9):5252-5265. doi: 10.1038/s41380-020-0769-6. Epub 2020 May 13. PMID:
32404948; PMCID: PMC8589670.

15: Navarro-Guerrero E, Tay C, Whalley JP, Cowley SA, Davies B, Knight JC, Ebner
D. Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell
(iPSC)-derived macrophages. Sci Rep. 2021 Feb 19;11(1):4245. doi:
10.1038/s41598-021-82137-z. PMID: 33608581; PMCID: PMC7895961.

16: Huang KA, Tan TK, Chen TH, Huang CG, Harvey R, Hussain S, Chen CP, Harding
A, Gilbert-Jaramillo J, Liu X, Knight M, Schimanski L, Shih SR, Lin YC, Cheng
CY, Cheng SH, Huang YC, Lin TY, Jan JT, Ma C, James W, Daniels RS, McCauley JW,
Rijal P, Townsend AR. Breadth and function of antibody response to acute SARS-
CoV-2 infection in humans. PLoS Pathog. 2021 Feb 26;17(2):e1009352. doi:
10.1371/journal.ppat.1009352. Erratum in: PLoS Pathog. 2021 Dec
10;17(12):e1010148. PMID: 33635919; PMCID: PMC8130932.

17: Washer SJ, Bassett AR, Cowley SA. Variation on a theme: mapping microglial
heterogeneity. Trends Genet. 2021 Dec;37(12):1050-1052. doi:
10.1016/j.tig.2021.09.004. Epub 2021 Sep 22. PMID: 34563398.

18: Ebrahimi KH, Gilbert-Jaramillo J, James WS, McCullagh JSO. Interferon-
stimulated gene products as regulators of central carbon metabolism. FEBS J.
2021 Jun;288(12):3715-3726. doi: 10.1111/febs.15625. Epub 2020 Dec 1. PMID:
33185982; PMCID: PMC8359365.

19: Badanjak K, Mulica P, Smajic S, Delcambre S, Tranchevent LC, Diederich N,
Rauen T, Schwamborn JC, Glaab E, Cowley SA, Antony PMA, Pereira SL, Venegas C,
Grünewald A. iPSC-Derived Microglia as a Model to Study Inflammation in
Idiopathic Parkinson’s Disease. Front Cell Dev Biol. 2021 Nov 5;9:740758. doi:
10.3389/fcell.2021.740758. PMID: 34805149; PMCID: PMC8602578.

20: Hall-Roberts H, Di Daniel E, James WS, Davis JB, Cowley SA. In vitro
Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-
Macrophages. J Vis Exp. 2021 Feb 14;(168). doi: 10.3791/62217. PMID: 33645588.

21: Burman RJ, Watson LM, Smith DC, Raimondo JV, Ballo R, Scholefield J, Cowley
SA, Wood MJA, Kidson SH, Greenberg LJ. Molecular and electrophysiological
features of spinocerebellar ataxia type seven in induced pluripotent stem cells.
PLoS One. 2021 Feb 24;16(2):e0247434. doi: 10.1371/journal.pone.0247434. PMID:
33626063; PMCID: PMC7904216.

22: Vaughan-Jackson A, Stodolak S, Ebrahimi KH, Browne C, Reardon PK, Pires E,
Gilbert-Jaramillo J, Cowley SA, James WS. Differentiation of human induced
pluripotent stem cells to authentic macrophages using a defined, serum-free,
open-source medium. Stem Cell Reports. 2021 Jul 13;16(7):1735-1748. doi:
10.1016/j.stemcr.2021.05.018. Epub 2021 Jun 24. Erratum in: Stem Cell Reports.
2021 Dec 14;16(12):3093. PMID: 34171284; PMCID: PMC8282471.

24: Huo J, Mikolajek H, Le Bas A, Clark JJ, Sharma P, Kipar A, Dormon J, Norman
C, Weckener M, Clare DK, Harrison PJ, Tree JA, Buttigieg KR, Salguero FJ, Watson
R, Knott D, Carnell O, Ngabo D, Elmore MJ, Fotheringham S, Harding A, Moynié L,
Ward PN, Dumoux M, Prince T, Hall Y, Hiscox JA, Owen A, James W, Carroll MW,
Stewart JP, Naismith JH, Owens RJ. A potent SARS-CoV-2 neutralising nanobody
shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat
Commun. 2021 Sep 22;12(1):5469. doi: 10.1038/s41467-021-25480-z. PMID: 34552091;
PMCID: PMC8458290.

25: Okarmus J, Havelund JF, Ryding M, Schmidt SI, Bogetofte H, Heon-Roberts R,
Wade-Martins R, Cowley SA, Ryan BJ, Færgeman NJ, Hyttel P, Meyer M.
Identification of bioactive metabolites in human iPSC-derived dopaminergic
neurons with PARK2 mutation: Altered mitochondrial and energy metabolism. Stem
Cell Reports. 2021 Jun 8;16(6):1510-1526. doi: 10.1016/j.stemcr.2021.04.022.
Epub 2021 May 27. PMID: 34048689; PMCID: PMC8190670.

26: Huo J, Bas AL, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK,
Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK,
Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree
JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James
W, Townsend AR, Stuart DI, Owens RJ, Naismith JH. Author Correction:
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with
ACE2. Nat Struct Mol Biol. 2021 Mar;28(3):326. doi: 10.1038/s41594-021-00566-w.
Erratum for: Nat Struct Mol Biol. 2020 Sep;27(9):846-854. PMID: 33536566; PMCID:
PMC7857722.

27: Girt GC, Lakshminarayanan A, Huo J, Dormon J, Norman C, Afrough B, Harding
A, James W, Owens RJ, Naismith JH. The use of nanobodies in a sensitive ELISA
test for SARS-CoV-2 Spike 1 protein. R Soc Open Sci. 2021 Sep 30;8(9):211016.
doi: 10.1098/rsos.211016. PMID: 34631127; PMCID: PMC8483265.

28: Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali
M, Hering LM, Meardon N, Austin J, Brown R, Skelly D, Gillson N, Dobson SL,
Cross A, Sandhar G, Kilby JA, Tyerman JK, Nicols AR, Spegarova JS, Mehta H,
Hornsby H, Whitham R, Conlon CP, Jeffery K, Goulder P, Frater J, Dold C, Pace M,
Ogbe A, Brown H, Ansari MA, Adland E, Brown A, Chand M, Shields A, Matthews PC,
Hopkins S, Hall V, James W, Rowland-Jones SL, Klenerman P, Dunachie S, Richter
A, Duncan CJA, Barnes E, Carroll M, Turtle L, de Silva TI; PITCH Consortium.
T-cell and antibody responses to first BNT162b2 vaccine dose in previously
infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective
cohort study. Lancet Microbe. 2022 Jan;3(1):e21-e31. doi:
10.1016/S2666-5247(21)00275-5. Epub 2021 Nov 9. PMID: 34778853; PMCID:
PMC8577846.

29: Peng Y, Felce SL, Dong D, Penkava F, Mentzer AJ, Yao X, Liu G, Yin Z, Chen
JL, Lu Y, Wellington D, Wing PAC, Dominey-Foy DCC, Jin C, Wang W, Hamid MA,
Fernandes RA, Wang B, Fries A, Zhuang X, Ashley N, Rostron T, Waugh C, Sopp P,
Hublitz P, Beveridge R, Tan TK, Dold C, Kwok AJ, Rich-Griffin C, Dejnirattisa W,
Liu C, Kurupati P, Nassiri I, Watson RA, Tong O, Taylor CA, Kumar Sharma P, Sun
B, Curion F, Revale S, Garner LC, Jansen K, Ferreira RC, Attar M, Fry JW,
Russell RA; COMBAT Consortium, Stauss HJ, James W, Townsend A, Ho LP, Klenerman
P, Mongkolsapaya J, Screaton GR, Dendrou C, Sansom SN, Bashford-Rogers R, Chain
B, Smith GL, McKeating JA, Fairfax BP, Bowness P, McMichael AJ, Ogg G, Knight
JC, Dong T. An immunodominant NP_105-113-B*07:02 cytotoxic T cell
response controls viral replication and is associated with less severe COVID-19
disease. Nat Immunol. 2022 Jan;23(1):50-61. doi: 10.1038/s41590-021-01084-z.
Epub 2021 Dec 1. PMID: 34853448; PMCID: PMC8709787.

30: Qiang M, Ma P, Li Y, Liu H, Harding A, Min C, Wang F, Liu L, Yuan M, Ji Q,
Tao P, Shi X, Li Z, Li T, Wang X, Zhang Y, Wu NC, Lee CD, Zhu X, Gilbert-
Jaramillo J, Zhang C, Saxena A, Huang X, Wang H, James W, Dwek RA, Wilson IA,
Yang G, Lerner RA. Neutralizing Antibodies to SARS-CoV-2 Selected from a Human
Antibody Library Constructed Decades Ago. Adv Sci (Weinh). 2022
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34716683; PMCID: PMC8646600.

2020 Publications

Ababneh, N. A., Scaber, J., Flynn, R., Douglas, A., Barbagallo, P., Candalija, A., Turner, M. R., Sims, D., Dafinca, R., Cowley, S. A., Cowley, S. A., & Talbot, K. (2020). Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair. Human Molecular Genetics, 29(13), 2200–2217. https://doi.org/10.1093/hmg/ddaa106

Andersson, M., barnes, eleanor, Beneke, T., Crook, D., Downs, L., Eyre, D., Harvala, H., James, W., Justice, A., Klenerman, P., & others. (2020). SARS-CoV-2 RNA in blood.

Borrmann, H., Davies, R., Dickinson, M., Pedroza-Pacheco, I., Schilling, M., Vaughan-Jackson, A., Magri, A., James, W., Balfe, P., Borrow, P., McKeating, J. A., & Zhuang, X. (2020a). Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication. Scientific Reports, 10(1), 13271. https://doi.org/10.1038/s41598-020-70170-3

Dafinca, R., Barbagallo, P., Farrimond, L., Candalija, A., Scaber, J., Ababneh, N. A., Sathyaprakash, C., Vowles, J., Cowley, S. A., & Talbot, K. (2020). Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD. Stem Cell Reports, 14(5), 892–908. https://doi.org/10.1016/j.stemcr.2020.03.023

Dodsworth, B. T., Hatje, K., Meyer, C. A., Flynn, R., & Cowley, S. A. (2020). Rates of homology directed repair of CRISPR-Cas9 induced double strand breaks are lower in naïve compared to primed human pluripotent stem cells. Stem Cell Research, 46. https://doi.org/10.1016/j.scr.2020.101852

Dodsworth, B. T., Hatje, K., Rostovskaya, M., Flynn, R., Meyer, C. A., & Cowley, S. A. (2020). Profiling of naïve and primed human pluripotent stem cells reveals state-associated miRNAs. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-67376-w

Ebrahimi, K. H., Howie, D., Rowbotham, J., McCullagh, J., Armstrong, F., & James, W. S. (2020a). Viperin, through its radical‐SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication. FEBS Letters, 1873-3468.13761. https://doi.org/10.1002/1873-3468.13761

Folegatti, P. M., Ewer, K. J., Aley, P., Angus, B., Becker, S., Belij-Rammerstorfer, S., Bellamy, D., Bibi, S., Bittaye, M., Clutterbuck, E. . E. A., Dold, C., Faust, S. N., Finn, A., Flaxman, A. L., Hallis, B., Heath, P., Jenkin, D., Lazarus, R., Makinson, R., … Yau, Y. (2020). Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. The Lancet, 396(10249), 467–478. https://doi.org/https://doi.org/10.1016/S0140-6736(20)31604-4

Gutbier, S., Wanke, F., Dahm, N., Rümmelin, A., Zimmermann, S., Christensen, K., Köchl, F., Rautanen, A., Hatje, K., Geering, B., Cowley, S. A., & Patsch, C. (2020). Large-scale production of human IPSC-derived macrophages for drug screening. International Journal of Molecular Sciences, 21(13), 1–23. https://doi.org/10.3390/ijms21134808

Hall-Roberts, H., Agarwal, D., Obst, J., Smith, T. B., Monzón-Sandoval, J., di Daniel, E., Webber, C., James, W. S., Mead, E., Davis, J. B., & Cowley, S. A. (2020). TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimer’s Research and Therapy, 12(1), 1–27. https://doi.org/10.1186/s13195-020-00709-z

Hedegaard, A., Stodolak, S., James, W. S., & Cowley, S. A. (2020a). Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.614972

Helene, B., Rhianna, D., Dickinson, M., Isabela, P.-P., Mirjam, S., Vaughan-Jackson, A., Magri, A., James, W., Balfe, P., Persephone, B., others, Borrmann, H., Davies, R., Dickinson, M., Pedroza-Pacheco, I., Schilling, M., Vaughan-Jackson, A., Magri, A., James, W., … Zhuang, X. (2020). Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication. Scientific Reports (Nature Publisher Group), 10(1), 13271. https://doi.org/10.1038/s41598-020-70170-3

Honarmand Ebrahimi, K., Rowbotham, J. S., McCullagh, J., & James, W. S. (2020a). Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2). ChemBioChem, 21(11), 1605–1612. https://doi.org/10.1002/cbic.201900776

Honarmand Ebrahimi, K., Vowles, J., Browne, C., McCullagh, J., & James, W. S. (2020). ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD⁺-dependent activity of enzymes to modulate metabolism. FEBS Letters, 594(10), 1631–1644. https://doi.org/10.1002/1873-3468.13778

Huo, J., le Bas, A., Ruza, R., Duyvesteyn, H. M. E., Mikolajek, H., Malinauskas, T., Tan, T. K., Rijal, P., Dumoux, M., Ward, P. N., Ren, J., Zhou, D., Harrison, P. J., Weckener, M., Clare, D. K., Vogirala, V. K., Radecke, J., Moynié, L., Zhao, Y., … Naismith, J. H. J. H. J. H. (2020a). Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nature Structural and Molecular Biology, 27(9), 1–9. https://doi.org/10.1038/s41594-020-0469-6

Lee, H., Flynn, R., Sharma, I., Haberman, E., Carling, P. J., Nicholls, F. J., Stegmann, M., Vowles, J., Haenseler, W., Wade-Martins, R., James, W. S., & Cowley, S. A. (2020a). LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages. Stem Cell Reports, 14(5), 940–955. https://doi.org/10.1016/j.stemcr.2020.04.001

Matthews, P. C., Andersson, M. I., Arancibia-Carcamo, C. V., Auckland, K., Baillie, J. K., Barnes, E., Beneke, T., Bibi, S., Brooks, T., Carroll, M., Wareing, S., Zambon, M., Crook, D., Dingle, K., Dold, C., Downs, L. O., Dunn, L., Eyre, D. W., Gilbert Jaramillo, J., … Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus [version 1; peer review: 1 approved with reservations]. Wellcome Open Research, 5(181), 181. https://doi.org/10.12688/wellcomeopenres.16002.1

Miao, X., Luo, Y., Huang, X., Lee, S. M. Y., Yuan, Z., Tang, Y., Chen, L., Wang, C., Wu, F., Xu, Y. Y., Jiang, W., Gao, W., Song, X., Yan, Y., Pang, T., Chen, C.-P., Zou, Y., Fu, W., Wan, L., … Xu, Y. Y. (2020). A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy. MAbs, 12(1), 1804241. https://doi.org/10.1080/19420862.2020.1804241

Muliyil, S., Levet, C., Düsterhöft, S., Dulloo, I., Cowley, S. A., & Freeman, M. (2020). ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration. EMBO Journal, 39(17). https://doi.org/10.15252/embj.2020104415

Roberts, H. H., Agarwal, D., Daniel, E. di, Webber, C., James, W. S., Mead, E., Davis, J. B., & Cowley, S. A. (2020). TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to TREM2 knockout in human IPSC-derived macrophages: Developing topics. Alzheimer’s \& Dementia, 16, e047388.

Sanghani, H. R., Jagannath, A., Humberstone, T., Ebrahimjee, F., Thomas, J. M., Churchill, G. C., Cipriani, A., Attenburrow, M.-J., Perestenko, O. V., Cowley, S. A., Goodwin, G. M., & Vasudevan, S. R. (2020). Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0769-6

Toombs, J., Panther, L., Ornelas, L., Liu, C., Gomez, E., Martín-Ibáñez, R., Cox, S. R., Ritchie, S. J., Harris, S. E., Taylor, A., Spires-Jones, T. L., & Sareen, D. (2020). Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Research, 46. https://doi.org/10.1016/j.scr.2020.101851

Wing, P. A., Keeley, T. P., Zhuang, X., Lee, J., Prange-Barczynska, M., Tsukuda, S., Morgan, S., Argles, I. la, Kurlekar, S., Noerenberg, M., Thompson, C. P., Huang, K.-Y. A., Balfe, P., Watashi, K., Castello Palomares, A., Hinks, T. S., James, W., Ratcliffe, P., Davies, I., … Mckeating, J. A. (2020). Hypoxic and Pharmacological Activation of HIF Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3720002

Zhou, D., Duyvesteyn, H. M. E., Chen, C.-P., Huang, C.-G., Chen, T.-H., Shih, S.-R. ., Lin, Y.-C., Cheng, C.-Y., Cheng, S.-H., Huang, Y.-C., Stuart, D. I., Huang, K.-Y. A., Lin, T.-Y., Ma, C., Huo, J., Carrique, L., Malinauskas, T., Ruza, R. R., Shah, P. N. M., … Huang, K.-Y. A. (2020). Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. Nature Structural & Molecular Biology, 27(10), 950–958. https://doi.org/10.1038/s41594-020-0480-y