William James

Professor of Virology | HEFCE | Brasenose College | william.james@path.ox.ac.uk

 

I am a virologist with a background in genetics and microbiology. My research interest since the mid-1980s has been largely focused on the AIDS virus, HIV-1, particularly how it replicates in macrophages and how smart nucleic acids can be developed to prevent its replication. I teach virology to medical students at Oxford University and am a Fellow of Brasenose College. I am also the University’s Pro Vice-Chancellor for Planning and Resource Allocation.

You can view my brief, introductions to evolutionary sciences, particularly population genetics and phylogenetics now on YouTube.

Read more...

Sally Cowley

Head, James Martin Stem Cell Facility | sally.cowley@path.ox.ac.uk

Sally Cowley joined the Sir William Dunn School  of Pathology as a Wellcome Trust Career Re-Entry Fellow in 2007, engaged in a program of research into the differentiation of human Pluripotent Stem Cell-derived macrophages and their applications for HIV studies. With William James, she has set up the James Martin Stem Cell Facility, affiliated to the Oxford Stem Cell Institutefor work with human Pluripotent Stem cells.

Collaborative projects she works on within this facility include:  iPSc-derived macrophages as a genetically-modifiable model system for understanding  macrophage biology; developing iPSc-microglia to study the contribution of microglia to neurodegenerative disease; generating iPS cells from Parkinson’s Disease patients as part of a large scale Oxford Parkinson’s Disease Centre research programme funded by Parkinson’s UK; EU IMI StemBANCC, which is establishing a panel of iPS derived cell lines from 500 patients as a platform for cellular phenotypic drug screening with industry partners; MRC DPUK Experimental Medicine Dementia Stem Cell Network, a UK-wide network (Oxford, Cambridge, UCL, Manchester, Cardiff, Edinburgh) using iPSc for modelling dementia.

Read more...

Kenny Moore

James Martin Stem Cell Fellow | James Martin Trust | Brasenose College | kenny.moore@path.ox.ac.uk
Kenny Moore is a James Martin Stem Cell Research Fellow,
using stem cells to investigate host-pathogen interactions of HIV-1.  Genetic manipulation plays an important role in uncovering the function of various proteins in any system, and using stem cell-derived macrophages, a technology developed within the James laboratory, Kenny is creating genetically modified macrophages for the study of HIV-1 infection.  Genetic manipulation of stem cells is also of paramount importance for their development as a therapeutic tool and Kenny is also involved in designing new strategies to accomplish this aim.

Hazel Hall-Roberts

Postdoctoral Research Assistant | ARUK ODDI | hazel.hall-roberts@path.ox.ac.uk

Dr Hazel Hall-Roberts (née Roberts) joined the lab in 2016, to research the role of microglia in Alzheimer’s disease. Microglia are immune cells that maintain a healthy brain environment by clearing up pathogens and ‘self’-made debris through a process called phagocytosis (‘cell eating’). Pathogens provoke a fuIl immune response, but ‘self’ debris usually does not. In an Alzheimer’s brain, microglial phagocytosis is impaired, and the microglia enter a state of chronic inflammation, in the absence of pathogens.  Hazel’s current project is jointly supervised by Dr Sally Cowley, and Dr Elena Di Daniel at the Alzheimer’s Research UK Oxford Drug Discovery Institute. Their main goal is to develop assays and tools for investigating microglial function in the context of Alzheimer’s disease, particularly their ability to clear neuronal debris via phagocytosis, using iPSC-derived macrophages as a cell model.

Hazel graduated from the University of Bristol in 2012 with a BSc in Biochemistry with Year in Industry, having spent a year working at GlaxoSmithKline Stevenage. At GlaxoSmithKline her research project looked at epigenetic proteins involved in the acute inflammation response of macrophages. This was followed by a PhD at the University of Bath (2012-16) with Professor David Brown, conducting research on α-synuclein, a protein that disrupts cell function in Parkinson’s disease, and how it promotes neuronal cell secretion of β-amyloid, a peptide that plays a key role in Alzheimer’s disease.

Jane Vowles

Research Assistant | jane.vowles@path.ox.ac.uk

Jane Vowles joined the Oxford University Dunn School of Pathology in 2010 as a research assistant generating iPS cells from Parkinson’s Disease patients as part of a large scale Oxford Parkinson’s Disease Centre research programme funded by Parkinson’s UK.

She graduated in Agriculture from Reading University in 1981 and began her career working on reproductive physiology of ruminants at the Agricultural Production Research Unit at Reading.

Read more...

Cecilia Lee

DPhil Student | Lincoln College | heyne.lee@path.ox.ac.uk

Benjamin Dodsworth

DPhil Student | Industrial BBSRC Case Studentship | Lincoln College | benjamin.dodsworth@lincoln.ox.ac.uk

Ben graduated from Sheffield University with a Master’s degree in molecular biology in 2014. Alongside his studies he worked in assay development for the biotech company R-Biopharm, and also took up a project at EMBL in Heidelberg working with mouse embryonic stem cells.  His focus on stem cell biology continued during his Master’s degree, working for Pfizer in the field of regenerative medicine. He has recently handed in his DPhil thesis on naïve human pluripotency, which he completed jointly in the William James Lab (Sir William Dunn School of Pathology) and at F. Hoffmann-La Roche in Basel. Ben has now secured pre-seed funding to commercialise findings of his thesis and his specific interests are the role of miRNAs in pluripotency and gene-editing.

Alun Vaughan-Jackson

DPhil Student | Wellcome Trust | Keble College | alun.vaughan-jackson@keble.ox.ac.uk

Alun is DPhil student on the Wellcome Trust Infection, Immunology, and Translational Medicine (IITM) doctoral programme. He started his journey into science doing a BSc Biomedical Sciences at UCL, from which he transferred to a BSc in Infection and Immunology for his final year. In this year he focussed his interests in infectious diseases onto virology, carrying out a dissertation project in the Tower’s lab working on new drug therapies for HIV-1 aiming to block interactions with host co-factors.

It was in the Tower’s lab that he first encountered and developed an interest in the Cyclophilins, a family of proteins with unclear functions and often found to interact with viruses. He wanted to see if they may be involved in the innate/antiviral immune response, but to achieve this he needed to knock out each family member. This ultimately led him to the James lab, where using their stem cell derived macrophages he has been able to explore the role of Cyclophilins in innate immunity and viral infections.