William James

Professor of Virology | HEFCE | Brasenose College | william.james@path.ox.ac.uk

I am a virologist with a background in genetics and microbiology. My research interest since the mid-1980s has been largely focused on the AIDS virus, HIV-1, particularly how it replicates in macrophages and how smart nucleic acids can be developed to prevent its replication. I teach virology to medical students at Oxford University and am a Fellow of Brasenose College. I am also the University’s Pro Vice-Chancellor for Planning and Resource Allocation.

You can view my brief, introductions to evolutionary sciences, particularly population genetics and phylogenetics now on YouTube.

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Sally Cowley

Head, James Martin Stem Cell Facility | sally.cowley@path.ox.ac.uk

Sally Cowley joined the Sir William Dunn School  of Pathology as a Wellcome Trust Career Re-Entry Fellow in 2007, engaged in a program of research into the differentiation of human Pluripotent Stem Cell-derived macrophages and their applications for HIV studies. With William James, she has set up the James Martin Stem Cell Facility, affiliated to the Oxford Stem Cell Institutefor work with human Pluripotent Stem cells.

Collaborative projects she works on within this facility include:  iPSc-derived macrophages as a genetically-modifiable model system for understanding  macrophage biology; developing iPSc-microglia to study the contribution of microglia to neurodegenerative disease; generating iPS cells from Parkinson’s Disease patients as part of a large scale Oxford Parkinson’s Disease Centre research programme funded by Parkinson’s UK; EU IMI StemBANCC, which is establishing a panel of iPS derived cell lines from 500 patients as a platform for cellular phenotypic drug screening with industry partners; MRC DPUK Experimental Medicine Dementia Stem Cell Network, a UK-wide network (Oxford, Cambridge, UCL, Manchester, Cardiff, Edinburgh) using iPSc for modelling dementia.

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Kenny Moore

James Martin Stem Cell Fellow | James Martin Trust | Brasenose College | kenny.moore@path.ox.ac.uk
Kenny Moore is a James Martin Stem Cell Research Fellow,
using stem cells to investigate host-pathogen interactions of HIV-1.  Genetic manipulation plays an important role in uncovering the function of various proteins in any system, and using stem cell-derived macrophages, a technology developed within the James laboratory, Kenny is creating genetically modified macrophages for the study of HIV-1 infection.  Genetic manipulation of stem cells is also of paramount importance for their development as a therapeutic tool and Kenny is also involved in designing new strategies to accomplish this aim.

Rowan Flynn

Career Development Fellow | StemBANCC | rowan.flynn@path.ox.ac.uk

Rowan Flynn recently joined the University of Oxford as a career development fellow to focus upon the development of gene editing techniques for use in stem cells. He is particularly interested in footprintless viral based methods of altering genomic sequence. Previously, he was a postdoctoral fellow at the University of Washington in Seattle, where his research focused on developing a treatment for Epidermolysis Bullosa (EB), which is caused by mutations in the gene encoding for collagen VII (COL7A1), the main component of anchoring fibrils that bind the epidermis to the underlying dermis. His approach was to produce skin grafts composed of genetically corrected patient-derived keratinocytes suitable for transplant.

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Walther Hänseler

Postdoc | Swiss National Science Foundation | walther.haenseler@path.ox.ac.uk

I started studying  biology at University of Zurich in 2004 and obtained the Bachelor of Science in Biology in 2007.
I did my master thesis in the group of Prof. Wolfgang Berger (Institute of Medical Genetics, University of Zurich, Schwerzenbach) “LRP5 and LRP5L mutation screening in patients with Norrie disease pseudoglioma-related phenotypes& Expression analysis of potential Norrin targets in Norrin knockout mouse cerebellum” and obtained the Master of Science in Biology, Neurosciences, from the University of Zurich in 2009.

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Jane Vowles

Research Assistant | jane.vowles@path.ox.ac.uk

Jane Vowles joined the Oxford University Dunn School of Pathology in 2010 as a research assistant generating iPS cells from Parkinson’s Disease patients as part of a large scale Oxford Parkinson’s Disease Centre research programme funded by Parkinson’s UK.

She graduated in Agriculture from Reading University in 1981 and began her career working on reproductive physiology of ruminants at the Agricultural Production Research Unit at Reading.

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Cecilia Lee

DPhil Student | Lincoln College | heyne.lee@path.ox.ac.uk

I graduated from Emory University receiving a bachelor’s degree in Neuroscience and Behavioral Biology (NBB). As an honours student, my research project focused on delineating topological pattern of dendritic spine loss in animal models of Parkinson’s disease (PD). This study illustrated that in the MPTP-treated monkeys, the loss of dendritic spines was most severely shown in the sensorimotor striatal territory, which may explain motor disturbance seen in PD.

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Benjamin Dodsworth

DPhil Student | Industrial BBSRC Case Studentship | Lincoln College | benjamin.dodsworth@lincoln.ox.ac.uk

Project title: Gene editing in naïve human pluripotent stem cells