Sarah H Ellwood | Postdoctoral Researcher

I joined the James Lab in May 2022 to reprogramme T Cells from Alzheimer’s disease patients into induced pluripotent stem cells (iPSCs) in collaboration with UKDRI Cardiff.

In July 2023 I started a Postdoc position as Oxford-GSK IMCM to generate and differentiate iPSCs from fibroblasts taken from Parkinson’s disease patients. The patients had been previously stratified into clusters determined by their disease progression. The mechanistic differences between clusters will be investigated by differentiating iPSCs into dopaminergic neurons and glia. We aim that through this work new therapeutic targets will be revealed.

I completed my PhD at the University of Plymouth, where I studied glial sensitivity to ischaemia, specifically astrocytes and oligodendrocytes. I also investigated the potential cell death mechanisms that may have been resposible for differences in sensitivity. Prior to this, I obtained my BSc in Biochemistry with Medical Biochemistry at the University of Leeds and completed a MSc in Molecular Medicine (Neuroscience) at the University of Sheffield. My research interests include iPSCs, neurodegenerative disease mechanisms, disease models and the role of glia in disease.

Image shows iPSCs generated in the James Lab