Projects on the tissue macrophage in SARS-CoV-2 and Neuroinflammation using human pluripotent stem cell and aptamer technologies
Role of alveolar macrophages in Covid19 pathology
This project is offered as part of our department’s Graduate Studentship competition, and builds on the development by Dr Sally Cowley in our lab of a hiPSC-derived model of the alveolar epithelium, including both type 2 pneumocytes and alveolar macrophages. The aim is to sue this genetically tractable and pathophysiologically relevant tissue-in-a-dish to study the severe tissue inflammation in the lungs, and the role of macrophages, viral products and therapeutic agents in modulating it. Further details, including background reading, can be seen here.