Latest group publications- C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 22 September 2023 Björn F Vahsen
- Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages 16 August 2023 Mirjam Schilling
- Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy 24 April 2023 Javier Gilbert-Jaramillo
- Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons 4 March 2023 Helle Bogetofte
- Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents 30 January 2023 Amy D Gelinas
- Density dependent regulation of inflammatory responses in macrophages 2 January 2023 Alun Vaughan-Jackson
- Type I interferon receptor (<em>IFNAR2</em>) deficiency reveals Zika virus cytopathicity in human macrophages and microglia 28 November 2022 Aidan T Hanrath
- Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations 17 November 2022 Yuxuan Ji
- Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia 14 November 2022 Sam J Washer
- Microglia states and nomenclature: A field at its crossroads 3 November 2022 Rosa C Paolicelli
William James
Professor of Virology | HEFCE | Brasenose College | william.james@path.ox.ac.uk
I am a virologist with a background in genetics and microbiology. My research interest since the mid-1980s has been largely focused on the AIDS virus, HIV-1, particularly how it replicates in macrophages and how smart nucleic acids can be developed to prevent its replication. I teach virology to medical students at Oxford University and am a Fellow of Brasenose College. For six yeats (2011-17) I was also the University’s Pro Vice-Chancellor for Planning and Resource Allocation.
You can view my brief, introductions to evolutionary sciences, particularly population genetics and phylogenetics now on YouTube.
Education |
Post-graduate Diploma in Learning and Teaching in Higher Education University of Oxford Dissertation on PBL and predictive assessment. Awarded distinction |
2001 |
Doctorate of Philosophy, MicrobiologyUniversity of OxfordGraduate supervisor, Professor Joel Mandelstam, FRS |
1984 | |
Bachelor of Science (Hons), Biological SciencesUniversity of BirminghamConcentration in Genetics |
1981 | |
Career HistorySubsidiary appointments in italics |
Associate Head (Finance Capital & Infrastructure),Division of Medical Sciences, University of Oxford |
2008 – date |
| Head of Department,Sir William Dunn School of Pathology, University of Oxford | 2007-8 | |
| Professor of Virology,Sir William Dunn School of Pathology, University of Oxford | 2006 – date | |
| Academic Bursar,Sir William Dunn School of Pathology, University of Oxford | 2005 – date | |
| Tutor in Medical Sciences, Brasenose College, Oxford | 2001 – date | |
| University Lecturer in Experimental Pathology,Sir William Dunn School of Pathology, University of Oxford | 1997 – 2006 | |
| Tutor in Medical Sciences, Magdalen College Oxford | 1997 – 2001 | |
| University Research Lecturer,Sir William Dunn School of Pathology, University of Oxford | 1994 – 1997 | |
| Monsanto Senior Research Fellow in Molecular Biology,Exeter College, Oxford | 1989 – 1994 | |
| Stipendiary Lecturer in Molecular Biology and Pathology,Christ Church and St Edmund Hall, Oxford | 1987 – 1989 | |
| Junior Research Fellow, Linacre College Oxford | 1985 – 1987 | |
| Departmental Demonstrator in Bacteriology,Sir William Dunn School of Pathology, University of Oxford | 1984 – 1989 | |