Latest group publications- Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy 24 April 2023 Javier Gilbert-Jaramillo
- Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons 4 March 2023 Helle Bogetofte
- Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents 30 January 2023 Amy D Gelinas
- Density dependent regulation of inflammatory responses in macrophages 2 January 2023 Alun Vaughan-Jackson
- Type I interferon receptor (<em>IFNAR2</em>) deficiency reveals Zika virus cytopathicity in human macrophages and microglia 28 November 2022 Aidan T Hanrath
- Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations 17 November 2022 Yuxuan Ji
- Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia 14 November 2022 Sam J Washer
- Microglia states and nomenclature: A field at its crossroads 3 November 2022 Rosa C Paolicelli
- Intranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice 28 October 2022 Lachlan P Deimel
- Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models 18 October 2022 Jimena Monzón-Sandoval
Maria Karabova
DPhil Student | Lincoln College | maria.karabova@path.ox.ac.uk
I am a DPhil student sponsored by the Oxford-E P Abraham Graduate Scholarship. My primary interest lies in the molecular pathology of Alzheimer’s disease. Currently, I am studying the processing of tau-protein aggregates by human iPSc-derived macrophages and microglia.
My academic journey started with a detour in medicine. During the studies, however, I realized that the methods and medication available, particularly with regards to the diseases of the brain, can often leave doctors applying plasters to gunshot wounds. A search for real advancements in the way we treat brain disorders led me to science. I completed my neuroscience training at the King’s College London in 2018 with a year in Industry at the UCI MIND Institute in California, USA. There, under the mentorship and supervision from Prof Carl Cotman, I worked on several projects, including the investigation of IL12/23-induced modulation of synaptic plasticity, elucidation of effective exercise patterns for long-term memory formation, and targeting H3K9me3 for treatment of cognitive decline associated with ageing and Alzheimer’s disease. Our work on the effect of early-life exercise on late-life cognitive reserve received the Gold Award in STEM for Britain 2018.