Latest group publications
- C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 22 September 2023 Björn F Vahsen
- Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages 16 August 2023 Mirjam Schilling
- Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy 24 April 2023 Javier Gilbert-Jaramillo
- Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons 4 March 2023 Helle Bogetofte
- Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents 30 January 2023 Amy D Gelinas
- Density dependent regulation of inflammatory responses in macrophages 2 January 2023 Alun Vaughan-Jackson
- Type I interferon receptor (<em>IFNAR2</em>) deficiency reveals Zika virus cytopathicity in human macrophages and microglia 28 November 2022 Aidan T Hanrath
- Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations 17 November 2022 Yuxuan Ji
- Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia 14 November 2022 Sam J Washer
- Microglia states and nomenclature: A field at its crossroads 3 November 2022 Rosa C Paolicelli
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Author Archives: William James
qPCR Facility
We maintain two Applied BioSystems QuantStudio 5 qPCR machines on behalf of the department, which are available for general use, in the instrument room, OMPI2 510.30.27. One is 96 well format and the other 384 well format. Iformation on these … Continue reading
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PhD op[portunity, see: https://www.findaphd.com/phds/project/exploring-parkinson-s-related-gene-function-in-hips-macrophages-and-microglia/?p66609
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Stem Cell Schools’ workshop
We worked with Science Oxford to show year 10 pupils from three Oxfordshire state schools something about the biology and potential of stem cells. See the video of the event at Voices from Oxford.
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PhD Project 2018: Investigating the biology of human tissue macrophages in health and disease
Apply here: https://www.findaphd.com/search/ProjectDetails.aspx?PJID=66609&LID=1238 Project Description Macrophages, such as the microglia of the brain, play essential homeostatic, remodelling, recycling and defence functions in all the tissues of the body. When they are overwhelmed by specialized pathogens such as HIV-1, or chronic accumulations … Continue reading
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Protection of HIV neutralizing aptamers against rectal and vaginal nucleases: Implications for RNA-based therapeutics
Author(s):Moore, M.D. | Cookson, J. | Coventry, V.K. | Sproat, B. | Rabe, L. | Cranston, R.D. | McGowan, I. | James, W.Publication year: 2011Journal / Book title: Journal of Biological Chemistry Access all results for your search in Scopus … Continue reading
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Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions
Author(s):van Wilgenburg, B. | Browne, C. | Vowles, J. | Cowley, S.A.Publication year: 2013Journal / Book title: PLoS ONE Access all results for your search in Scopus …read more Source:: cowley, sally a.” 7102482900 “james, william s.” 35479049300 “moore, michael … Continue reading
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Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration
Author(s):Zhou, L. | Sokolskaja, E. | Jolly, C. | James, W. | Cowley, S.A. | Fassati, A.Publication year: 2011Journal / Book title: PLoS Pathogens Access all results for your search in Scopus …read more Source:: “james, william s.” 35479049300
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CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells
Author(s):Flynn, R. | Grundmann, A. | Renz, P. | Hänseler, W. | James, W.S. | Cowley, S.A. | Moore, M.D.Publication year: 2015Journal / Book title: Experimental Hematology Access all results for your search in Scopus …read more Source:: cowley, sally … Continue reading
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Multiplex High-Throughput Targeted Proteomic Assay to Identify Induced Pluripotent Stem Cells
Author(s):Baud, A. | Wessely, F. | Mazzacuva, F. | McCormick, J. | Camuzeaux, S. | Heywood, W.E. | Little, D. | Vowles, J. | Tuefferd, M. | Mosaku, O. | Lako, M. | Armstrong, L. | Webber, C. | Cader, … Continue reading
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MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons
Author(s):Beevers, J.E. | Lai, M.C. | Collins, E. | Booth, H.D.E. | Zambon, F. | Parkkinen, L. | Vowles, J. | Cowley, S.A. | Wade-Martins, R. | Caffrey, T.M.Publication year: 2017Journal / Book title: Stem Cell Reports Access all results … Continue reading
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