Latest group publications
- C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 22 September 2023 Björn F Vahsen
- Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages 16 August 2023 Mirjam Schilling
- Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy 24 April 2023 Javier Gilbert-Jaramillo
- Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons 4 March 2023 Helle Bogetofte
- Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents 30 January 2023 Amy D Gelinas
- Density dependent regulation of inflammatory responses in macrophages 2 January 2023 Alun Vaughan-Jackson
- Type I interferon receptor (<em>IFNAR2</em>) deficiency reveals Zika virus cytopathicity in human macrophages and microglia 28 November 2022 Aidan T Hanrath
- Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations 17 November 2022 Yuxuan Ji
- Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia 14 November 2022 Sam J Washer
- Microglia states and nomenclature: A field at its crossroads 3 November 2022 Rosa C Paolicelli
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qPCR Facility
We maintain two Applied BioSystems QuantStudio 5 qPCR machines on behalf of the department, which are available for general use, in the instrument room, OMPI2 510.30.27. One is 96 well format and the other 384 well format. Iformation on these … Continue reading
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PhD op[portunity, see: https://www.findaphd.com/phds/project/exploring-parkinson-s-related-gene-function-in-hips-macrophages-and-microglia/?p66609
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Macrophages from human pluripotent stem cells
Author(s):Cowley, S.A. | Karlsson, K.R. | van Wilgenburg, B. | Carter, G.C. | Browne, C. | Vowles, J. | Estrada, F.M. | Pelchen-Matthews, A. | Miller, J. | Moore, M.D. | James, W.Publication year: 2012Journal / Book title: Handbook of … Continue reading
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Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism
Author(s):Rakovic, A. | Domingo, A. | Grütz, K. | Kulikovskaja, L. | Capetian, P. | Cowley, S.A. | Lenz, I. | Brüggemann, N. | Rosales, R. | Jamora, D. | Rolfs, A. | Seibler, P. | Westenberger, A. | König, … Continue reading
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FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
Author(s):Künzel, U. | Grieve, A.G. | Meng, Y. | Sieber, B. | Cowley, S.A. | Freeman, M.Publication year: 2018Journal / Book title: eLife Access all results for your search in Scopus …read more Source:: cowley, sally a.” 7102482900 “james, william … Continue reading
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Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease
Author(s):Vazquez-Arango, P. | Vowles, J. | Browne, C. | Hartfield, E. | Fernandes, H.J.R. | Mandefro, B. | Sareen, D. | James, W. | Wade-Martins, R. | Cowley, S.A. | Murphy, S. | O’Reilly, D.Publication year: 2016Journal / Book title: … Continue reading
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Multiplex High-Throughput Targeted Proteomic Assay to Identify Induced Pluripotent Stem Cells
Author(s):Baud, A. | Wessely, F. | Mazzacuva, F. | McCormick, J. | Camuzeaux, S. | Heywood, W.E. | Little, D. | Vowles, J. | Tuefferd, M. | Mosaku, O. | Lako, M. | Armstrong, L. | Webber, C. | Cader, … Continue reading
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
Author(s):Haenseler, W. | Sansom, S.N. | Buchrieser, J. | Newey, S.E. | Moore, C.S. | Nicholls, F.J. | Chintawar, S. | Schnell, C. | Antel, J.P. | Allen, N.D. | Cader, M.Z. | Wade-Martins, R. | James, W.S. | Cowley, … Continue reading
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Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trial
Author(s):Hakim, J.G. | Thompson, J. | Kityo, C. | Hoppe, A. | Kambugu, A. | van Oosterhout, J.J. | Lugemwa, A. | Siika, A. | Mwebaze, R. | Mweemba, A. | Abongomera, G. | Thomason, M.J. | Easterbrook, P. | … Continue reading
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Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1
Author(s):Jonikas, M. | Madill, M. | Mathy, A. | Zekoll, T. | Zois, C.E. | Wigfield, S. | Kurzawa-Akanbi, M. | Browne, C. | Sims, D. | Chinnery, P.F. | Cowley, S.A. | Tofaris, G.K.Publication year: 2018Journal / Book title: … Continue reading
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